Heart rate changes during freezing of gait in patients with Parkinson's disease
Identifieur interne : 000696 ( Main/Exploration ); précédent : 000695; suivant : 000697Heart rate changes during freezing of gait in patients with Parkinson's disease
Auteurs : Inbal Maidan [Israël] ; Meir Plotnik [Israël] ; Anat Mirelman [Israël, États-Unis] ; Aner Weiss [Israël] ; Nir Giladi [Israël] ; Jeffrey M. Hausdorff [Israël, États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
English descriptors
Abstract
Freezing of gait (FOG) is one of the most disabling symptoms that affect patients with Parkinson's disease (PD). Although the pathophysiology underlying FOG largely remains an enigma, several lines of evidence suggest that the autonomic nervous system might be involved. To this end, we tested the hypothesis that heart rate (HR) increases during FOG and, further, that HR increases just before FOG. To evaluate these hypotheses, 15 healthy older adults, 10 patients with PD who experienced FOG, and 10 patients who did not were studied. Patients with PD were tested during their “off” medication state. HR and HR variability were measured as subjects carried out tasks that frequently provoke FOG; 120 FOG episodes were evaluated. During FOG, HR increased (P = 0.001) by an average of 1.8 bpm, compared with HR measured before the beginning of FOG. HR also increased just before FOG, by 1 bpm (P < 0.0001). In contrast, during sudden stops and 180° turns, HR decreased by almost 2 bpm (P < 0.0001). HR variability was not associated with FOG. To our knowledge, these findings are the first to document the association of FOG to autonomic system activation, as manifested by HR dynamics. One explanation is that the changes in HR before and during FOG may be a sympathetic response that, secondary to limbic activation, contributes to the development of freezing. Although further studies are needed to evaluate these associations, the current results provide experimental evidence linking impaired motor blockades to autonomic nervous system function among patients with PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23280
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heart rate changes during freezing of gait in patients with Parkinson's disease</title><author><name sortKey="Maidan, Inbal" sort="Maidan, Inbal" uniqKey="Maidan I" first="Inbal" last="Maidan">Inbal Maidan</name></author><author><name sortKey="Plotnik, Meir" sort="Plotnik, Meir" uniqKey="Plotnik M" first="Meir" last="Plotnik">Meir Plotnik</name></author><author><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name></author><author><name sortKey="Weiss, Aner" sort="Weiss, Aner" uniqKey="Weiss A" first="Aner" last="Weiss">Aner Weiss</name></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></author><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6E5D5E50D419FD31DBB5C62B2889C07A09D21EAF</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23280</idno><idno type="url">https://api.istex.fr/document/6E5D5E50D419FD31DBB5C62B2889C07A09D21EAF/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001026</idno><idno type="wicri:Area/Main/Curation">000E37</idno><idno type="wicri:Area/Main/Exploration">000696</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Heart rate changes during freezing of gait in patients with Parkinson's disease</title><author><name sortKey="Maidan, Inbal" sort="Maidan, Inbal" uniqKey="Maidan I" first="Inbal" last="Maidan">Inbal Maidan</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Tel‐Aviv Sourasky Medical Center, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Physical Therapy, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Plotnik, Meir" sort="Plotnik, Meir" uniqKey="Plotnik M" first="Meir" last="Plotnik">Meir Plotnik</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Tel‐Aviv Sourasky Medical Center, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Tel‐Aviv Sourasky Medical Center, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Weiss, Aner" sort="Weiss, Aner" uniqKey="Weiss A" first="Aner" last="Weiss">Aner Weiss</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Tel‐Aviv Sourasky Medical Center, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Tel‐Aviv Sourasky Medical Center, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Tel‐Aviv Sourasky Medical Center, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Physical Therapy, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv</wicri:regionArea><wicri:noRegion>Tel‐Aviv</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30">2010-10-30</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2346">2346</biblScope><biblScope unit="page" to="2354">2354</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6E5D5E50D419FD31DBB5C62B2889C07A09D21EAF</idno><idno type="DOI">10.1002/mds.23280</idno><idno type="ArticleID">MDS23280</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>autonomic nervous system</term><term>freezing of gait</term><term>gait</term><term>heart rate</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Freezing of gait (FOG) is one of the most disabling symptoms that affect patients with Parkinson's disease (PD). Although the pathophysiology underlying FOG largely remains an enigma, several lines of evidence suggest that the autonomic nervous system might be involved. To this end, we tested the hypothesis that heart rate (HR) increases during FOG and, further, that HR increases just before FOG. To evaluate these hypotheses, 15 healthy older adults, 10 patients with PD who experienced FOG, and 10 patients who did not were studied. Patients with PD were tested during their “off” medication state. HR and HR variability were measured as subjects carried out tasks that frequently provoke FOG; 120 FOG episodes were evaluated. During FOG, HR increased (P = 0.001) by an average of 1.8 bpm, compared with HR measured before the beginning of FOG. HR also increased just before FOG, by 1 bpm (P < 0.0001). In contrast, during sudden stops and 180° turns, HR decreased by almost 2 bpm (P < 0.0001). HR variability was not associated with FOG. To our knowledge, these findings are the first to document the association of FOG to autonomic system activation, as manifested by HR dynamics. One explanation is that the changes in HR before and during FOG may be a sympathetic response that, secondary to limbic activation, contributes to the development of freezing. Although further studies are needed to evaluate these associations, the current results provide experimental evidence linking impaired motor blockades to autonomic nervous system function among patients with PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Israël</li><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="Israël"><noRegion><name sortKey="Maidan, Inbal" sort="Maidan, Inbal" uniqKey="Maidan I" first="Inbal" last="Maidan">Inbal Maidan</name></noRegion><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name><name sortKey="Maidan, Inbal" sort="Maidan, Inbal" uniqKey="Maidan I" first="Inbal" last="Maidan">Inbal Maidan</name><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name><name sortKey="Plotnik, Meir" sort="Plotnik, Meir" uniqKey="Plotnik M" first="Meir" last="Plotnik">Meir Plotnik</name><name sortKey="Weiss, Aner" sort="Weiss, Aner" uniqKey="Weiss A" first="Aner" last="Weiss">Aner Weiss</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name></region><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000696 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000696 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:6E5D5E50D419FD31DBB5C62B2889C07A09D21EAF
|texte= Heart rate changes during freezing of gait in patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |